MOTS-C

MOTS-C is a naturally occurring mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome, consisting of 16 amino acids. Supplied as a lyophilized powder in a sealed laboratory-grade glass vial. Intended for in-vitro and laboratory research applications only.

Research Context
MOTS-C is studied in in-vitro and animal-model research into AMP-activated protein kinase (AMPK) signalling, a pathway central to cellular energy homeostasis. In research models it has been observed to translocate to the nucleus under metabolic-stress conditions, making it a subject of interest for investigating nuclear gene-expression and adaptive stress-response pathways. Its association with the folate cycle and de novo purine synthesis, AICAR accumulation, and subsequent AMPK activation is examined in research contexts alongside glucose-uptake, insulin-signalling, and mitochondrial-biogenesis pathways. This mitochondria-to-nucleus signalling profile makes it a subject of interest in metabolic-pathway, insulin-signalling, and cellular-longevity research.

Specifications
• Sequence: Validated by mass spectrometry (MS/MS)
• Purity: ≥ 99% by HPLC
• Form: Lyophilized powder
• Molecular Weight: 2,174.4 Da
• Storage: 2 – 8 °C, keep dry and away from light
• Shelf Life: 24 months from manufacture date (sealed)

Quality & Testing
Every batch is independently tested by a certified third-party laboratory. A Certificate of Analysis (CoA) confirming purity and identity is available for each batch.